Caryophyllene is considered a highly important terpene because, unlike other terpenes, it is able to activate CB2 receptors throughout the body. This unique trait makes caryophyllene very similar to the cannabinoid CBD because both can be used to eliminate pain, minimize inflammation, and reduce stress. Multiple studies show that as a functional CB2 agonist, caryophyllene has the ability to reduce inflammation, which in turn, helps to alleviate pain. The unique way in which this terpene relieves full-body pain has been a revelation for scientists, because no other terpene has yet been documented to manipulate the endocannabinoid system. Besides being useful for reducing inflammation and pain, caryophyllene has also exhibited stress reducing and anti-depressant properties in mice. Not only that, but some studies also suggest that this terpene can act as a neuroprotectant as well. More research is needed on this front, but the findings are unsurprising given what is already known about CBD. Furthermore, caryophyllene can also be used as an antifungal to eliminate dermatophytes, which are known to cause skin diseases such as ringworm.